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Nevirapine
Catalog NO.: API-004
| CAS NO.: 129618-40-2 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, API
Synonyms:
11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2’,3’-e][1,4]diazepin-6-one;
BI-RG 587; NSC 641530; Nevarapine; Viramune
Molecular Formula
C15H14N4O
Molecular Weight
266.30
General description
Nevirapine is widely utilized in
research focusing on the study of viral replication mechanisms, particularly in
the context of HIV. Researchers employ Nevirapine to investigate its inhibitory
effects on the reverse transcriptase enzyme, which is critical in the HIV
replication process. This application is fundamental in understanding how viral
resistance to inhibitors develops over time, and what strategies might be more
effective in curbing viral proliferation at the molecular level. Additionally,
Nevirapine serves as a tool in the study of chemical interactions and metabolic
pathways in virology research labs, providing insights into how different
compounds can influence the activity of enzymes involved in virus replication.
Pharmaceutical secondary
standards for application in quality control, provide pharma laboratories and
manufacturers with a convenient and cost-effective alternative to the
preparation of in-house working standards. Nevirapine is a non-nucleoside
reverse transcriptase inhibitor (NNRTI), which belongs to the class of
antiretroviral drugs. It acts by inhibiting the reverse transcriptase enzyme,
thus suppressing the multiplication of HIV. It is highly effective against the
advanced HIV disease.
Application
Nevirapine may be used as a
pharmaceutical reference standard for the determination of the analyte in
pharmaceutical formulations and fixed dose combinations by chromatography.
These Secondary Standards are
qualified as Certified Reference Materials. These are suitable for use in
several analytical applications including but not limited to pharma release
testing, pharma method development for qualitative and quantitative analyses,
food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
NNRTI (non-nucleoside reverse
transcriptase inhibitor) of HIV-1
Nevirapine is an allosteric,
non-nucleoside inhibitor of HIV reverse transcriptase (NNRTI). The Ki for
inhibition of wild-type RT by Nevirapine is 200 nM.