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Zidovudine
Catalog NO.: API-002
| CAS NO.: 30516-87-1 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, 2’-deoxy
Synonyms:
AZT, Azidothymidine, ZDV, Zidovudine
3’-Azido-3’-deoxythymidine
Molecular Formula
C10H13N5O4
Molecular Weight
267.3
General description
3’-Azido-3’-deoxythymidine has
been used as the reverse transcriptase inhibitor to inhibit the viral genome
integration and as an antimicrobial agent to evaluate its anti-Salmonella
activity.
Biochem/physiol Actions
Azidothymidine (AZT), a
thymidine analogue, is a reverse transcriptase inhibitor against the HIV-1
virus. Azidothymidine has been shown to decrease CRISPR-mediated
homology-directed repair (HDR) efficiency.
Reverse transcriptase inhibitor
active against HIV-1 virus.
3’-Azido-3-deoxythymidine (AZT), a nucleoside analog,
has been extensively researched for its biochemical properties and its role in
nucleic acid synthesis. As a nucleoside reverse transcriptase inhibitor (NRTI),
AZT impedes the replication of retroviruses, including HIV, by competitively
inhibiting the reverse transcriptase enzyme essential for viral DNA synthesis.
AZT has been pivotal in elucidating the molecular mechanisms of retroviral
replication and the development of antiviral therapies. Researchers have
employed AZT as a tool to dissect the intricacies of reverse transcription and
to explore potential targets for antiretroviral therapy development. Moreover,
AZT′s incorporation into viral DNA by reverse transcriptase and
subsequent chain termination have provided insights into the structure-function
relationship of nucleoside analogs and their impact on DNA synthesis. Studies
have focused on optimizing AZT′s pharmacokinetic properties
and enhancing its antiviral efficacy through chemical modifications.
Furthermore, AZT has been utilized in research investigating nucleoside analog
toxicity and resistance mechanisms. By studying AZT′s
interactions with cellular enzymes and nucleic acids, researchers aim to
improve the design and efficacy of antiviral agents while minimizing adverse
effects.
Zidovudine is a nucleoside reverse transcriptase inhibitor
(NRTI), widely used to treat HIV infection. Zidovudine increases
CRISPR/Cas9-mediated editing frequency.