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Bucladesine Sodium
Salt
Catalog NO.: CMP-002 | CAS NO.: 16980-89-5 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, Nucleotide
Synonyms:
Cyclic AMP; cAMP; Adenosine 3',5'-cyclophosphate;
4H-Furo[3,2-d]-1,3,2-dioxaphosphorin-7-ol, 6-(6-amino-9H-purin-9-yl)tetrahydro-2-hydroxy-, 2-oxide, (4aR,6R,7R,7aS)-; cyclic
Adenosine 3',5'-monophosphate
N6,2′-O-Dibutyryladenosine 3′,5′-cyclic
monophosphate sodium salt
Bucladesine
sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt
Molecular Formula
C18H23N5NaO8P
Molecular Weight
491.37
General description
Bucladesine
sodium salt (Dibutyryl-cAMP sodium salt) is a
stabilized cyclic AMP (cAMP) analog and a selective PKA activator. Bucladesine sodium salt raises the intracellular levels of
cAMP. Bucladesine sodium salt is also a
phosphodiesterase (PDE) inhibitor. Bucladesine sodium
salt has anti-inflammatory activity and can be used for impaired wound healing.
Dibutyrylcyclic
adenosine monophosphate (cAMP) mimics the activity of endogenous cAMP.It is lipophilic, allows it to be more cell-permeable,
and has higherresistance towards hydrolysis by cAMP
phosphodiesterase. Dibutyryl cAMPinhibits
phosphodiesterases and plays a vital role as a probe
in signaltransduction pathways.
Application
It has been used as a component of the differentiation
medium to induce differentiationof dopaminergic
neurons from floor plate progenitors. It has also been usedasa supplement in DMEM: F12 to culture neuronal
cells from human pluripotent stemcells.
N6,2′-O-Dibutyryladenosine 3′,5′-cyclic
monophosphate sodium salt has been used:
as a medium supplement for neural crest stem cells (NCSCs)
differentiation
as a component of thawing medium for cryopreserved human
iPSC (induced pluripotent stem cell)-derived neurons
in serum-free Dulbecco′s modified eagle′s
medium (DMEM) to induce astrocyte differentiation
Biochem/physiol Actions
Cell-permeable cAMP analog that activates cAMP dependent
protein kinase (PKA).