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Guanosine 5'-triphosphate disodium
Catalog NO.: NTP-003
| CAS NO.: 56001-37-7 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, Nucleotide
Synonyms
GTP-Na2; Guanosine 5'-(tetrahydrogen
triphosphate) sodium salt (1:2); Guanosine 5'-(tetrahydrogen
triphosphate) disodium salt; 5'-GTP disodium salt; Disodium 5'-GTP; Disodium
guanosine triphosphate; GTP disodium salt; Guanosine 5'-triphosphoric acid
disodium salt
Molecular Formula
C10H14N5Na2O14P3
Molecular Weight
587.14
General description
Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G
protein (G proteins) signaling activator and a high-energy precursor in the
biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate
trisodium salt can promote myogenic cell differentiation by upregulating miRNA
(miR133a, miR133b) and myogenic regulatory factor expression, and by inducing
human myogenic precursor cells to release exosomes containing guanosine
molecules. Guanosine-5'-triphosphate disodium salt holds promise for research
in biosynthesis and skeletal muscle regeneration.
Guanosine 5′-triphosphate
(GTP) is a purine trinucleotide. GTP is a substrate for a wide range of
G-protein coupled receptor (GPCR) GTPases, as well as cell signaling and
cycling-associated guanine nucleotide exchange factors (GEF). See product G3776
for RNA polymerase transcription and DNA or RNA biosynthesis applications.
Application
Guanosine 5′-triphosphate
sodium salt hydrate has been used:
- as
a component of the internal solution for astrocyte patch-clamp to monitor
astrocyte calcium activity from mouse amygdala slices.
- in
a solution for channel current recording in cell lines using a
voltage-clamp technique.
- to
prepare internal recording solution for injectoporation
to deliver genes to mechanosensory hair cells.
- promoting
the formation of G interface-mediated homodimers of human septin during the analysis of its oligomerization
state by analytical size exclusion chromatography (SEC).