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Inosine 5'-triphosphate trisodium salt
Catalog NO.: NTP-005
| CAS NO.: 35908-31-7 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, Nucleotide
Synonyms
Inosine 5'-(Tetrahydrogen
Triphosphate) Trisodium Salt; NSC 20266; Trisodium Inosine-5'-triphosphate;
ITP; 9H-Purin-6-ol, 9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-,
sodium salt (1:3); Trisodium
5'-O-[({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphinato]inosine
ITP Na3
Molecular Formula
C10H12N4O14P3.3Na
Molecular Weight
574.11
General description
Inosine-5'-triphosphate trisodium salt is a nucleoside
triphosphate and functions as an substrate for ATPases
and GTPases.
Inosine 5′-triphosphate
(ITP) is used in studies on the impact of deamination of ATP and GTP by various
enzymes and chemical processes. ITP may be used as a substrate to study the
specificity and kinetics of nucleoside-5′-triphosphatase and ATPase. ITP is also used to
study activation of various ATPases and GTPases.
Inosine 5′-triphosphate
trisodium salt has been used to investigate its influence on the chromosome
aberration rate, the mitotic rate, sister-chromatid exchange (SCE) frequency,
the proportion of first (X1), second (X2) and third (X3) division metaphases of
human peripheral lymphocytes.
Biochem/physiol Actions
Inosine 5′-triphosphate
(ITP) has the ability to support the initiation of
effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD). ITP
can proficiently induce secretion in permeabilized cells than GTP.[2] Instead
of GTP, ITP can be used for the initiation and the elongation steps of reovirus
transcription.[3] ITP can also replace GTP in the activation of G-protein.