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Phytol

Specification:	1) Yellow to orange transparent sticky liquid  2) Easily decomposed in light, easily soluble in chloroform and vegetable oil, ethyl ether and ethanol. 3) Insoluble in water.
Application:	It is a basic raw material for production of Vitamin K1 and Vitamin E. Phytol is a by-product from the production of chlorophyll

Phytol: Nature’s Versatile Biomolecule for Health and Innovation

Phytol, a branched-chain diterpene alcohol (C₂₀H₄₀O), is a ubiquitous component of chlorophyll, the essential pigment driving photosynthesis in plants, algae, and cyanobacteria (Fischer, 1928; Wilstätter, 1909). As a hydrolysis product of chlorophyll, it is one of the most abundant acyclic isoprenoids in the biosphere, offering a sustainable and naturally derived resource for biomedical and industrial applications (Rontani & Volkman, 2003). At Biocaxis, we harness the potential of phytol through advanced extraction and purification techniques, delivering high-purity phytol for cutting-edge solutions in pharmaceuticals, nutraceuticals, and cosmetics.

Natural Origins and Biomedical Significance
Phytol’s unique structure underpins its diverse bioactivities. Studies highlight its antioxidant, antimicrobial, and anti-inflammatory properties, making it a candidate for therapeutic development (Islam et al., 2018; de Moraes et al., 2014). For instance, phytol induces apoptosis and autophagy in cancer cells, offering promise in oncology, while its anxiolytic effects suggest applications in mental health (Kowalczyk et al., 2021). Additionally, phytol derivatives, such as γ-butyrolactones, exhibit enhanced cytotoxic activity against leukemia and lung carcinoma cells, underscoring its versatility in drug design (Kowalczyk et al., 2021).

Industrial and Cosmetic Applications
Beyond therapeutics, phytol is a cornerstone in fragrances and cosmetics due to its grassy aroma and stabilizing properties (Silva et al., 2024). It serves as a precursor for synthetic vitamins E and K1, critical for skincare and nutritional supplements (Al-Harrasi et al., 2019). Biocaxis prioritizes eco-friendly extraction methods, sourcing phytol from renewable plant-based materials to ensure sustainability and safety, avoiding risks associated with animal-derived alternatives (Gutbrod et al., 2021).

Commitment to Innovation
Biocaxis leverages phytol’s molecular adaptability to develop tailored formulations. Our phytol is rigorously tested for purity (>98%) and low endotoxin levels, ideal for sensitive applications like gene therapy carriers or functional food additives (Vetter & Schröder, 2010). Recent advancements in enzymatic and chemical synthesis further enhance its bioavailability, enabling breakthroughs in metabolic disorder treatments and antimicrobial agents (Silva et al., 2024).

Explore how Biocaxis’s phytol can elevate your product pipeline, backed by cutting-edge research and a commitment to ecological stewardship.

References

1. Al-Harrasi, A., et al. (2019). Acyclic diterpenes. In Natural Product Biosynthesis (pp. 189–210). Elsevier. DOI: 10.1016/B978-0-12-816455-6.00009-3
2. de Moraes, J., et al. (2014). Phytol, a diterpene alcohol from chlorophyll, as a drug against neglected tropical disease schistosomiasis mansoni. PLOS Neglected Tropical Diseases, 8(1), e2617. DOI: 10.1371/journal.pntd.0002617
3. Fischer, F. G. (1928). Structure of phytol. Berichte der Deutschen Chemischen Gesellschaft, 61(1), 2400–2406.
4. Gutbrod, K., et al. (2021). Phytol derived from chlorophyll hydrolysis in plants is a key intermediate in stress-induced aldehyde accumulation. Journal of Biological Chemistry, 296, 100530. DOI: 10.1016/j.jbc.2021.100530
5. Islam, M. T., et al. (2018). Phytol: A review of biomedical activities. Food and Chemical Toxicology, 121, 82–94. DOI: 10.1016/j.fct.2018.08.032
6. Kowalczyk, M., et al. (2021). Synthesis of novel phytol-derived γ-butyrolactones and evaluation of their biological activity. Scientific Reports, 11, 4262. DOI: 10.1038/s41598-021-83736-6
7. Rontani, J. F., & Volkman, J. K. (2003). Phytol degradation products as biogeochemical tracers in aquatic environments. Organic Geochemistry, 34(1), 1–35. DOI: 10.1016/S0146-6380(02)00185-7
8. Silva, A., et al. (2024). New phytol derivatives with increased cosmeceutical potential. Molecules, 29(20), 4917. DOI: 10.3390/molecules29204917
9. Vetter, W., & Schröder, M. (2010). Phytanic acid and pristanic acid in dairy products. Journal of Agricultural and Food Chemistry, 58(1), 553–560. DOI: 10.1021/jf903065m
10. Wilstätter, R. (1909). Hydrolysis of chlorophyll. Annalen der Chemie, 373(1), 177–204.

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