Biocaxis > Products > deoxynucleotide |
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2'-Deoxyadenosine-5'-monophosphate
Catalog NO.: DNT-001 | CAS NO.: 653-63-4 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, 2’-deoxyNucleotide
Synonyms:
2′-Deoxy-AMP, 2′-Deoxyadenylic acid, dAMP
Molecular Formula
C10H14N5O6P
Molecular Weight
331.22
General description
General description
N2′-Deoxyadenosine 5′-monophosphate is a
nucleotide that serves as a building block for DNA synthesis.
2′-Deoxyadenosine 5′-monophosphate, a nucleic
acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine
5′-monophosphate can be used to study adenosine-based interactions during
DNA synthesis and DNA damage.
2'-Deoxyadenosine-5'-monophosphate free acid (2DAMP) is a
nucleoside analogue that can be used as a fluorescent probe for detecting water
vapor. 2DAMP has been shown to have cytotoxic activity against solid tumours in
vitro, and may act by hydrogen bonding interactions with the active site of the
enzyme form. 2DAMP is also an important cofactor in the polymerase chain
reaction, and can inhibit cellular proliferation by inhibiting nuclear DNA
synthesis. This drug has been used as an active antiretroviral therapy, where
it inhibits HIV-1 reverse transcriptase. 2DAMP's mechanism of action involves
the inhibition of p-nitrophenyl phosphate reductase (PNPPR), which is
responsible for converting p-nitrophenyl phosphate into p-nitrophenol.
Application
2’-deoxyadenosine-5’-monophosphatehas been used to study
proteins via UV resonance Raman spectroscopy.