Biocaxis > Products > deoxynucleotide |
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2′-Deoxycytidine 5′-monophosphate
Catalog NO.: DNT-002 | CAS NO.: 1032-65-1 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, 2’-deoxyNucleotide
Synonyms:
Deoxycytidylic acid, dCMP
Molecular Formula
C9H14N3O7P
Molecular Weight
307.20
General description
2′-Deoxycytidine 5′-monophosphate is a
deoxynucleotide building block via which DNA is made. It consists of a 2′-deoxy-β-D-ribofuranose,
linked through an N-β-D-glycosidic linkage to a heterocycle nitrogen
cytosine. It is phosphorylated at carbon C-5′.
2'-Deoxycytidine-5'-monophosphate (dCMP) is a nucleotide
that is synthesized by the enzyme cytidine monophosphate synthetase. It has
been shown to inhibit the activity of many enzymes, including those involved in
DNA synthesis and repair. The incorporation of dCMP into DNA can be used as a
probe for studying various biological processes, such as radiation damage and
cellular physiology. In addition, it has been shown that dCMP inhibits the
growth of human osteosarcoma cells. This drug is also used in combination
preparations with other drugs, such as with 5-fluorouracil and doxorubicin, to
treat cancer tumors.
Application
2′-Deoxycytidine 5′-monophosphate (dCMP) is
used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP)
kinase (EC 2.7.4.4) to form dCDP which upon phosphorylation to dCTP supports
DNA biosynthesis.
2′-Deoxycytidine 5′-monophosphate has been used
in Raman spectroscopic studies to determine its Raman total half bandwidths.