Biocaxis > Products > deoxynucleoside |
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2'-Deoxy-L-Uridine
Catalog NO.: L-DNS-004 | CAS NO.: 31501-19-6 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, 2’-deoxy
Synonyms:
9-(2-Deoxy-b-L-erythro-pentofuranosyl) uracil
Molecular Formula
C9H12N2O5
Molecular Weight
228.20
General description
2'-Deoxy-β-L-uridine is a nucleoside
analogue and a specific substrate for the viral enzyme, shows no
stereospecificity against herpes simplex 1 (HSV1) thymidine kinase (TK). 2′-Deoxy-β-L-uridine
exerts antiviral activity via the interaction of 5'-triphosphates with the
viral DNA polymerase.
2'-Deoxy-L-uridine is a nucleoside that is found in the
human body. It phosphorylates l-thymidine, which is a natural substrate, and
this reaction prevents the formation of diphosphate from d-ribose
5'-monophosphate. 2'-Deoxy-L-uridine is an exogenous substance that inhibits
cell growth by affecting protein synthesis and DNA replication.
2'-Deoxy-L-uridine has been shown to be more efficient than wild type uridine
in inhibiting cell growth in vitro at concentrations of 1 mM or greater. The
enantiomers of 2'-deoxy-L-uridine affect cell growth differently, with the
(R)-enantiomer being more potent than the (S)-enantiomer.