Biocaxis > Products > deoxynucleoside |
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2'-Deoxy-L-guanosine
Catalog NO.: L-DNS-003 | CAS NO.: 22837-44-1 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, 2’-deoxy
Synonyms:
9-(2-Deoxy-b-L-erythro-pentofuranosyl) guanine
Torcitabine
Molecular Formula
C10H13N5O4
Molecular Weight
267.25
General description
2'-Deoxy-L-guanosine selectively inhibits D-Thymidine
phosphorylation catalyzed by HSV 1 thymidine kinase. 2'-Deoxy-L-guanosine is
the L-configuration of 2'-Deoxyguanosine.
2'-Deoxy-L-guanosine is a nucleoside that is used as an
antibiotic. It inhibits protein synthesis, which leads to cell death. This drug
has a high level of resistance against bacteria and is effective in the
treatment of gram-positive bacteria. 2'-Deoxy-L-guanosine binds to the ribose
phosphate backbone of DNA, phosphorylating it and preventing the base pairing
of adenosine with thymine. This inhibits the production of DNA and RNA, leading
to cell death. 2'-Deoxy-L-guanosine has been shown to be active against
Listeria monocytogenes and Mycobacterium tuberculosis. The enantiomer form is
more potent than the racemic mixture, but both forms are effective antibiotics.