Biocaxis > Products > deoxynucleoside |
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2'-Deoxyuridine
Catalog NO.: D-N-005 | CAS NO.: 951-78-0 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, 2’-deoxy
Synonyms:
1-(2-Deoxy-β-D-ribofuranosyl)uracil, Uracil
deoxyriboside
Molecular Formula
C9H12N2O5
Molecular Weight
228.20
General description
’-deoxyuridine is a brain-penetrant pyrimidines nucleotide
that is associated with nervous system diseases. 2'-Deoxyuridine could increase
chromosome breakage and results in a decreased thymidylate synthetase activity.
2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and
also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine
reduces microglial activation and improve oxidative stress damage by modulating
glycolytic metabolism on the Aβ25-35-induced brain injury, which is
promising for research of Alzheimer’s disease (AD).
Application
2′-Deoxyuridine has been used as a:
precursor of [3H]thymidine triphosphate (TTP) in place of
thymidine to avoid a potential thymidine block in relative proliferation assays
nucleoside supplement for cell cycle synchronization and
DNA replication inhibition
mitotic inhibitor in culture media to minimize the
proliferation of glial cells