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2′-Deoxy-2′-fluoroadenosine 

Catalog NO.: F-M-001 | CAS NO.: 64183-27-3 | Brand: BIOCAXIS

Category

Nucleosides & Nucleotides, 2’-modified

Synonyms:

2'-F-2'-dA, 5-(6-amino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol, (2R,3R,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol

Molecular Formula

C₁₀H₁₂FN₅O₃

Molecular Weight

269.23

General description

2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP

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