Biocaxis > Products > deoxynucleoside |
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2′-Deoxyinosine
Catalog NO.: D-N-006 | CAS NO.: 890-38-0 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, 2’-deoxy
Synonyms:
9-(2-Deoxy-β-D-ribofuranosyl)hypoxanthine
Molecular Formula
C10H12N4O4
Molecular Weight
252.23
General description
2’-deoxyadenosine inhibits the growth of human
colon-carcinoma cell lines and is found to be associated with purine nucleoside
phosphorylase (PNP) deficiency.
Application
2′-Deoxyinosine has been used in the quantification
of nucleoside forms of DNA lesion in a single DNA sample by liquid
chromatography tandem mass spectrometry (LC-MS/MS). It has also been used as a
standard for high performance liquid chromatography analysis.
Biochem/physiol Actions
2′-Deoxyinosine is a nucleoside composed of
hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond.
2′-Deoxyinosine in DNA can arise from deamination of adenosine. 2′-deoxyinsine
can be used as a model compound to study the chemistry of adduct formation and
radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used
to produce hybridization-sensitive fluorescent DNA probes with self-avoidance
ability.
2′-Deoxyinosine is a nucleoside form of hypoxanthine.
It is a DNA damage product resulting from the impairment of DNA by reactive
nitrogen species. 2′-deoxyinosine is formed from nitrosative deamination
by N2O3.