Biocaxis > Products > deoxynucleoside |
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3'-Deoxythymidine
Catalog NO.: DD-N-004 | CAS NO.: 3416-05-5 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, 2’-deoxy
Synonyms:
2’,3’-dideoxythymidine
ddT
1-[5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
Molecular Formula
C10H14N2O4
Molecular Weight
226.23
General description
3′-Deoxythymidine (2′,3′-Dideoxythymidine),
a nucleoside analog, inhibits eukaryotic cellular and viral DNA polymerases,
and inhibits retrovirus infection in some cells
3'-Deoxythymidine (3DT) is a nucleoside analog that has
high resistance to HIV. It is an analogue of the human insulin-like growth
factor-1 (IGF-1), which binds to the IGF-1 receptor and inhibits the binding of
IGF-1 to its receptor, thereby inhibiting the growth of cells. 3DT has been
shown to have a protective effect against radiation in mice, with an LD50 at a
dose of 5.0 mg/kg for radiation exposure. 3DT also has antiviral activity
against murine sarcoma virus, as well as other biological properties such as
enzyme activities and disease activity. This drug may be used in future
research on polymerase chain reactions (PCRs) and DNA sequencing, since it is
chemically stable and can be easily synthesized.