Biocaxis > Products > deoxynucleoside |
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Gemcitabine
Catalog NO.: F-M-005
| CAS NO.: 95058-81-4 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, 2’-modified
Synonyms:
2′-Deoxy-2′,2′-difluorocytidine;
dFdC, Gemzar (Lilly), LY-188011, dFdC, dFdCyd
2'-Deoxy-2',2'-difluorocytidine;
2'-Deoxy-2',2'-difluoro-D-cytidine; 2',2'-Difluoro-2'-deoxycytidine;
4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;
2',2'-Difluorodeoxycytidine; DDFC; DFdC; Folfugem; GemLip; Gemcel; NSC 613327;
Gemzar
Molecular Formula
C9H11F2N3O4
Molecular Weight
263.20
General description
Gemcitabine is a nucleoside analogue used in chemotherapy.
It treats cancers including testicular cancer, breast cancer, ovarian cancer,
non-small cell lung cancer, pancreatic cancer and bladder cancer.
Gemcitabineis a pyrimidine nucleoside analog of
deoxycytidine. It exhibits anticancereffects against various cancers.
Application
Gemcitabinehydrochloride has been used as a
chemotherapeutic agent to study its effects onthe human pancreatic
adenocarcinoma cell line. It has
been used as a chemotherapeutic to study its resistance inpancreatic stellate
cells (PSCs). It has also been used
to study its effects on patient-derivedxenograft (PDX) organoids.
Biochem/physiol Actions
Gemcitabine is a widely used antitumor agents in both
clinics and research labs. It is an antineoplastic agent and antimetabolite.