Biocaxis > Products > Nucleoside |
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5-Azacytidine
Catalog NO.: NS-001
| CAS NO.: 320-67-2 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, nucleobase
Synonyms:
5-Azacitidine, 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one,
Ladakamycin
Azacitidine; Azacytidine; Ladakamycin
Molecular Formula
C8H12N4O5
Molecular Weight
244.20
General description
5-azacytidine is a pyrimidine nucleoside analog that
specifically inhibits DNA methylation by trapping DNA methyltransferases.
5-Azacytidine is a chemical analog of cytidine. It
functions as a hypomethylating agent. 5-Azacytidine is used to treat
myelodysplastic syndrome (MDS).
Chemical structure: nucleoside
Application
5-Azacytidine has been used:
for cell induction
to study its effects on bovine fetal mesenchymal stem cells
(bfMSC)
to study its effects on human bone marrow stromal cells (hBMSCs)
to study its effects on and DNA methyltransferase 1 (DNMT1)
and Ras protein activator like 1 (RASAL1) expression
to interfere with DNA methylation and histone acetylation
to determine its effects on the conversion of control
fibroblasts
for optical coherence tomography (OCT) and fluorescein
angiography (FA)
for the reactivation of Sal-like protein (SALL)3 expression
Biochem/physiol Actions
5-Azacytidine (Aza-CR) acts as a potential chemotherapeutic
regimen for acute myelogenous leukemia. This drug has an ability to selectively
increase γ-globin synthesis. Therefore, 5-azacytidine is used in treating
severe β-thalassemia. Aza-CR acts as a potential bacteriostatic, antitumor
and mutagenic agent. In addition, it also exhibits various biological activity
such as, immunosuppressive, antimitotic, radioprotective and virostatic effects.
A potent growth inhibitor and cytotoxic agent; inhibits DNA
methyltransferase, an important regulatory mechanism of gene expression, gene
activation and silencing.
Causes DNA demethylation or hemi-demethylation, creating
openings that allow transcription factors to bind to DNA and reactivate tumor
suppressor genes.
Potent growth inhibitor and cytotoxic agent; inhibits DNA
methyltransferase.