Biocaxis > Products > Nucleoside |
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Arauridine
Catalog NO.: NS-004
| CAS NO.: 3083-77-0 |
Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, nucleobase
Synonyms:
Arauridine;
1-(β-D-Arabinofuranosyl)uracil;
Uracil-1-β-D-arabinofuranoside;
1-β-D-Arabinofuranosyl-2,4(1H,3H)-pyrimidinedione; Ara-U; Arabinosyluracil; NSC 68928; Uracil Arabinoside; Cytarabine
Impurity A; Cytarabine EP Impurity A;
1-β-D-arabinofuranosylpyrimidine-2,4(1H,3H)-dione
Uracil 1-β-D-arabinofuranoside; 1-beta-D-Arabinofuranosyluracil
Arauridine, Spongouridin,
1-β-D-Arabinofuranosyluracil
Molecular Formula
C9H12N2O6
Molecular Weight
244.20
General description
-beta-D-Arabinofuranosyluracil
(Uracil 1-β-D-arabinofuranoside) isolated from
the Caribbean sponge Tectitethya crypta, is a methoxyadenosine derivative.
1-beta-D-Arabinofuranosyluracil has demonstrated a diverse bioactivity profile
including anti-inflammatory activity, analgesic and vasodilation properties.
1-beta-D-Arabinofuranosyluracil reduces a proliferation of mouse lymphoma
cells.
1-β-d-arabinofuranosyluracil
(Ara-U) is the detoxification product or metabolite of
1-β-d-arabinofuranosylcytosine (Ara-C). Uracil 1-β-D-arabinofuranoside is the human metabolite of a cytostatic
agent called cytarabine (CYT).
Application
Uracil 1-β-D-arabinofuranoside
may be used as a reference compound in the analysis of cytostatics
and metabolites in hospital wastewater by hydrophilic interaction
chromatography/tandem mass spectrometry to demonstrate its analytical
possibilities and limitations.[4] It may also be used as a standard for
chemical analysis to investigate the ecotoxicity and genotoxicity of cytotoxic
antineoplastic drugs, like cytarabine (CYT) and their metabolites, like
uracil-1-β-d-arabinofuranoside (AraU).