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Guanosine
Catalog NO.: NS-013
| CAS NO.: 118-00-3 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, nucleobase
Synonyms:
2-Amino-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one;
6H-Purin-6-one, 2-amino-1,9-dihydro-9-β-D-ribofuranosyl-;
DL-Guanosine; Guanine ribonucleoside; Guanine, 9-β-D-ribofuranosyl-;
Inosine, 2-amino-; NSC 19994; Vernine;
β-D-Ribofuranoside, guanine-9; ribo Guanosine
9-(β-D-Ribofuranosyl)guanine,
Guanine-9-β-D-ribofuranoside
Molecular Formula
C10H13N5O5
Molecular Weight
283.24
General description
Guanosine is a purine nucleoside comprising guanine
attached to a ribose (ribofuranose) ring via a β-N9-glycosidic
bond.
Guanosine (DL-Guanosine) is a purine nucleoside comprising
guanine attached to a ribose (ribofuranose) ring via
a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.
Application
Guanosine has been used:
as a ribonucleoside component of the basal medium to study
its effects on Bacillus mojavensis′s anaerobic
growth
as a component of the Dulbecco′s modified Eagle
medium (DMEM) to culture mouse-derived embryonic stem cells
as a component of the nucleoside solution to culture
chicken embryonic stem cells
Biochem/physiol Actions
Guanosine is a purine nucleoside that exhibits important
functions in cell metabolism. It has also shown neuroprotective and
neurotrophic effects in glial cells, hippocampal neurons, and pheochromocytoma
cells by inducing proliferation and differentiation and also exerting
anti-apoptotic effects. Guanosine acts as a therapeutic agent against several neuropathologies. It exerts its effects against
sepsis-induced cognitive impairment, hepatic encephalopathy, lipopolysaccharide
(LPS)-induced inflammation, ischemic injury, and azide-induced
oxidative damage. Guanosine is suitable for use in cell culture applications as
a precursor of guanosine monophosphate (GMP), guanosine diphosphate (GDP),
guanosine triphosphate (GTP), and cyclic GMP (cGMP).