Biocaxis > Products > Nucleoside |
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Inosine
Catalog NO.: NS-015
| CAS NO.: 58-63-9 |
Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, nucleobase
Synonyms:
(−)-Inosine, Hypoxanthine 9-β-D-ribofuranoside
1,9-Dihydro-9-β-D-ribofuranosyl-6H-purin-6-one;
9-β-D-Ribofuranosylhypoxanthine; Hypoxanthine
9-β-D-ribofuranoside; Hypoxanthine
Ribonucleoside; Hypoxanthine Riboside; Hypoxanthosine;
Ribonosine; Atorel; Oxiamin; Trophicardyl; Selfer; ribo Inosine; HXR; Ino; Inosie; NSC 20262
Molecular Formula
C10H12N4O5
Molecular Weight
268.23
General description
Inosine is an endogenous purine nucleoside produced by
catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive,
immunomodulatory and neuroprotective effects. Inosine is an agonist for
adenosine A1 (A1R) and A2A (A2AR) receptors.
Inosine is a nucleoside that is formed when hypoxanthine is
attached to a ribose ring (also known as a ribofuranose)
via a β-N9-glycosidic bond.
Inosine is a non-canonical nucleotide majorly present as
monophosphate. It has ability to base pair with deoxythymidine, deoxyadenosine
and deoxyguanosine. Incorporation of inosine in place of guanine modulates
translational events. Inosine has antioxidant, anti-inflammatory and
neuroprotective functionality. Inosine is prescribed as a therapeutic
supplement for nerve injury, inflammation and oxidative stress. It modulates
biological processes through adenosine receptors. Its enhances neurite
outgrowth in depressive disorders via adenosine receptors. Inosine is also used
for treating sepsis in infections.
Application
Inosine has been used:
as a medium supplement in nucleotide rescue experiments in
pancreatic cancer cell lines.
as a component in holidic
(synthetic) medium and in larval two-choice preference assay.
as a reference standard in mass spectroscopy.