Biocaxis > Products > Nucleoside |
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L-5-methyluridine
Catalog NO.: L-NS-006
| CAS NO.: 21138-24-9 | Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, L-nucleoside
Synonyms:
1-(b-L-ribofuranosyl) 5-methyluracil
Molecular Formula
C10H14N2O
Molecular Weight
178.23
General description
L-5-methyluridine is a nucleoside that is used as a
building block in the synthesis of oligonucleotides. It contains one ribose
sugar and one deoxyribose sugar, linked to the base adenine by a phosphate
group. L-5-methyluridine can be synthesized from 5-chloro-2'-deoxyadenosine,
hypoxanthine, and ammonium chloride. The synthesis starts with condensation
reactions between the two sugar molecules to form an intermediate called a
nucleoside. This is followed by alkylation of the base and then oxidation of the
sugar group to form anomeric esters. The last step involves hydrolysis of the
acyloxy ester, which yields L-5-methyluridine after acidification.