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Vidarabine
Catalog NO.: NS-002
| CAS NO.: 5536-17-4 |
Brand: BIOCAXIS
Category
Nucleosides & Nucleotides, nucleobase
Synonyms:
Ara-adenosine; 9-β-D-Arabinofuranosyladenine;
9-(b-D-Arabinofuranosyl)adenine; Adenine arabinoside;
Arabinosyladenine; Spongoadenosine;
Araadenosine; Arabinosyl
adenine;
(2R,3S,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;
9-β-D-Arabinofuranosyl-9H-purin-6-amine; Adenine Arabinofuranoside
Adenine 9-β-D-arabinofuranoside; 9-β-D-Arabinofuranosyladenine,
Ara-A, Vidarabine
Molecular Formula
C10H13N5O4
Molecular Weight
267.24
General description
Vidarabine (Ara-A) an antiviral agent which is active
against herpes simplex and varicella zoster viruses. Vidarabine has IC50s of
9.3 μg/ml for HSV-1 and 11.3 μg/ml
for HSV-2. Vidarabine also has anti-orthopoxvirus
activity.
Adenine 9-β-D-arabinofuranoside
(AraA) is a nucleoside analog. It is an antiviral drug and targets viral DNA
polymerases and is majorly used for treating herpes simplex viral infection. It
is a potent inhibitor of AMP-activated protein kinase (AMPK). It also inhibits
cardiac type 5 adenylyl cyclase but does not improve pathology in
cardiovascular diseases.
Application
Adenine 9-β-D-arabinofuranoside
has been used for the inhibition of 5′ AMP-activated protein kinase
(AMPK) in liver, muscle[and cardiac
cells H9c2.
Used to study the roles of AMP-activated protein kinase
(AMPK) in cell signaling.
Biochem/physiol Actions
Cell-permeable adenylate cyclase inhibitor; in
detergent-dispersed rat brain preparation, IC50 = 30 μM.
Clinically significant antiviral agent, especially against herpes simplex
(HSV), by inhibition of DNA polymerase.
Cell-permeable adenylyl cyclase inhibitor. IC50 = 30 μM in detergent-dispersed rat brain preparation.